반응 #50577

반응 방정식

chloroacetonitrile

2,3-dichloro-thiophenol

sodium methanolate

→

2,3-dichloro-phenylthioacetonitrile

수율 59.1%

용매

methanol

반응 조건

후처리

1. 1
   workup.ADDITIONare added in portions
2. 2
   온도with cooling
3. 3
   workup.STIRRINGthe mixture is stirred for 2 hours at room temperature and for a further 5 hours
4. 4
   온도at reflux temperature
5. 5
   여과The entire batch is then filtered while hot and
6. 6
   농축concentrated in vacuo

실험 절차

15.0 g (83.8 mmol) of 2,3-dichloro-thiophenol are introduced into 50 ml of absolute methanol, 4.5 g (83.8 mmol) of sodium methanolate are added in portions, with cooling, and the mixture is stirred for 15 minutes at room temperature. 6.3 g (83.8 mmol) of chloroacetonitrile are subsequently added dropwise, and the mixture is stirred for 2 hours at room temperature and for a further 5 hours at reflux temperature. The entire batch is then filtered while hot and concentrated in vacuo. 10.8 g (59.1% of theory) of 2,3-dichloro-phenylthioacetonitrile are obtained.

출처