반응 #50560

반응 방정식

ethyl isonipecotate

bromotoluene

triethylamine

→

ethyl 1-benzylpiperidine-4-carboxylate

수율 88.9%

용매

methylene chloride

반응 조건

후처리

1. 1
   세척The mixture was washed with brine
2. 2
   기타the organic layer was separated
3. 3
   기타dried
4. 4
   농축concentrated

실험 절차

A mixture of ethyl isonipecotate (69.25 g, 0.441 mol). -bromotoluene (75.44 g, 52.4 ml, 0.441 mol) and triethylamine (44.74 g, 61.5 ml, 0.441 mol) in 1000 ml methylene chloride was stirred at r.t. for 20 hr. The mixture was washed with brine and the organic layer was separated, dried and concentrated to give 97.016 g of ethyl 1-benzylpiperidine-4-carboxylate as a yellow oil. HNMR (CDCl)δ 1.2(t, 3H), 1.6-1.9 (m, 4H), 2.0 (dt, 2H), 2.2-2.3 (m, 1H), 2.85 (m, 2H), 3.5 (s, 2H), 4.1 (q, 2H), 7.2-7.36 (m, 5H) ppm.

출처