반응 #505532

ord-4256ec0fd27041d69ff4bd6d6f593a98

반응 방정식

CC(C)(C)OC(=O)N[C@H]1CCc2nc(NC(=O)OCc3ccccc3)sc2C1
((S)-6-tert-butoxycarbonylamino-4,5,6,7-tetrahydro-benzothiazol-2-yl)-carbamic acid benzyl ester
O=C(O)C(F)(F)F
TFA
→
N[C@H]1CCc2nc(NC(=O)OCc3ccccc3)sc2C1.O=C(O)C(F)(F)F
((S)-6-amino-4,5,6,7-tetrahydro-benzothiazol-2-yl)-carbamic acid benzyl ester trifluoroacetate

반응물

CC(C)(C)OC(=O)N[C@H]1CCc2nc(NC(=O)OCc3ccccc3)sc2C1
((S)-6-tert-butoxycarbonylamino-4,5,6,7-tetrahydro-benzothiazol-2-yl)-carbamic acid benzyl ester
O=C(O)C(F)(F)F
TFA

시약

없음

용매

ClCCl
CH2Cl2

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    농축Concentrated

실험 절차

Dissolved ((S)-6-tert-butoxycarbonylamino-4,5,6,7-tetrahydro-benzothiazol-2-yl)-carbamic acid benzyl ester in 20 mL of CH2Cl2. Added 20 mL of TFA. Stirred for 1 h. LC-MS analysis indicated complete deprotection of BOC group. Concentrated to give 46.0 g of ((S)-6-amino-4,5,6,7-tetrahydro-benzothiazol-2-yl)-carbamic acid benzyl ester trifluoroacetate as pale yellow solid.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08093266B2uspto-grants-2012_01