반응 #50522

반응 방정식

1,5-dimethyl-4-hydroxymethyl-2-(4-trifluoromethylphenyl)imidazole

→

1,5-dimethyl-4-formyl-2-(4-trifluoromethylphenyl)imidazole

수율 100.8%

용매

chloroform

반응 조건

후처리

1. 1
   온도was refluxed for 24 hours
2. 2
   온도the mixture refluxed for a further 3 hours
3. 3
   온도The mixture was cooled
4. 4
   여과the solid material filtered off
5. 5
   세척washed with methylene chloride
6. 6
   기타The solvent was removed from the filtrate under reduced pressure

실험 절차

A mixture of 1,5-dimethyl-4-hydroxymethyl-2-(4-trifluoromethylphenyl)imidazole (0.5 g) and manganese dioxide (2 g) in 20 ml of chloroform was refluxed for 24 hours. A further 2 g of manganese dioxide was added, and the mixture refluxed for a further 3 hours. The mixture was cooled, the solid material filtered off, and washed with methylene chloride. The solvent was removed from the filtrate under reduced pressure, to yield 0.5 g of 1,5-dimethyl-4-formyl-2-(4-trifluoromethylphenyl)imidazole, m.p. 144° C.

출처