반응 #50479
ord-b3474fe4b48448968a054c9f00a56b80
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타quenched with water
- 2기타separated
- 3세척The organic phase was washed with 5 mL of H2O, 5 mL of saturated NaHCO3, and 5 mL of brine
- 4건조dried over Na2SO4
- 5기타evaporated
실험 절차
A solution of 1.00 g (4.5 mmol) of (E,E)-farnesol (Aldrich, further purified by flash chromatography) in 10 mL of distilled ether at 0° C. under argon in the dark was treated dropwise with a solution of 195 μL (2.05 mmol, 0.45 eq.) of PBr3 in 2 mL of diethyl ether (ether). The resultant mixture was stirred at 0° C. for one hour, then quenched with water and separated. The organic phase was washed with 5 mL of H2O, 5 mL of saturated NaHCO3, and 5 mL of brine, dried over Na2SO4 and evaporated to give 1.26 g (98%) of crude bromide as a clear oil.