반응 #504425

반응 방정식

6-bromo-2-oxindole

3-chloro-2-fluorobenzaldehyde

piperidine

→

Z-6-bromo-3-(3-chloro-2-fluoro-benzylidene)-1,3-dihydro-indol-2-one

수율 94.0%

용매

methanol

반응 조건

후처리

1. 1
   온도After cooled to 4° C.
2. 2
   여과the mixture was filtered
3. 3
   기타resulting precipitate
4. 4
   기타was collected
5. 5
   기타dried

실험 절차

To the mixture of 6-bromo-2-oxindole (5 g, 24 mmol) (Combi-blocks) and 3-chloro-2-fluorobenzaldehyde (3.7 g, 24 mmol) (Oakwood) in methanol (200 mL) was added piperidine (2 g, 24 mmol) (Aldrich) dropwise. The mixture was then heated at 80° C. for 2 h. After cooled to 4° C., the mixture was filtered and resulting precipitate was collected, dried to give E/Z-6-bromo-3-(3-chloro-2-fluoro-benzylidene)-1,3-dihydro-indol-2-one as a yellow solid (Yield 7.8 g, 94%).

출처