반응 #50427

반응 방정식

stannous octoate

lauryl alcohol

glycolide

L-lactide

→

GLYCOLIC ACID LACTIC ACID

용매

toluene

반응 조건

후처리

1. 1
   workup.ADDITIONwere added to the reactor
2. 2
   온도While the temperature was maintained as it
3. 3
   추출One hour after the start of the deaeration, the monomers and low-molecular substances were not extracted any more, and the interior of the reactor

실험 절차

1161 g (10 mols) of glycolide and 1441 g (10 mols) of L-lactide were placed in a glass reactor, and 10 ml of a toluene solution containing 0.26 g of stannous octoate and 9.0 g of lauryl alcohol were added to the reactor. Afterward, deaeration was carried out for 2 hours under reduced pressure, and the atmosphere in the reactor was then replaced with a nitrogen gas. This mixture was heated at 220° C. for 2 hours with stirring under the nitrogen atmosphere. While the temperature was maintained as it was, the deaeration was slowly preformed by means of a vacuum pump through an exhaust pipe to reduce the pressure in the reactor to 3 mm Hg. One hour after the start of the deaeration, the monomers and low-molecular substances were not extracted any more, and the interior of the reactor was replaced with nitrogen and a resultant glycolic acid-lactic acid copolymer (hereinafter referred to as "PLGA") was then taken out.

출처