반응 #5040

반응 방정식

HCl

nitrile

4-benzyloxybenzonitrile

triethylamine hydrochloride

sodium azide

→

5-(4-benzyloxyphenyl)tetrazole

수율 98.1%

용매

water

DMF

반응 조건

후처리

1. 1
   온도under reflux for 18 hrs
2. 2
   기타The resulting white solid was collected
3. 3
   세척washed with water
4. 4
   기타dried at 60° C. in vacuo for 48 hrs

실험 절차

A mixture of 285 g of the nitrile, 262.5 g triethylamine hydrochloride and 124 g of sodium azide in 1.5 L of DMF under nitrogen was stirred under reflux for 18 hrs. The reaction mixture was cooled to room temperature, poured into 4 L of cold water and acidified with 3N HCl. The resulting white solid was collected, washed with water and dried at 60° C. in vacuo for 48 hrs to give 337 g of 5-(4-benzyloxyphenyl)tetrazole.

출처