반응 #50394

반응 방정식

4-chlorobenzenesulphonic acid chloride

6-(4-(2-aminoethyl)phenyl)-6-(3-pyridyl)hexanoic acid

potassium carbonate

→

6-(4-(2-(4-Chlorobenzenesulphonylamino)ethyl)phenyl)-6-(3-pyridyl)hexanoic acid

용매

dioxan

dioxan

반응 조건

후처리

1. 1
   기타After 5 hours it is rotary evaporated to dryness
2. 2
   기타precipitated with dilute acetic acid
3. 3
   기타The precipitate is collected
4. 4
   기타dried
5. 5
   기타chromatographed over a silica gel column

실험 절차

1.9 g of 6-(4-(2-aminoethyl)phenyl)-6-(3-pyridyl)hexanoic acid are suspended in 150 ml of dioxan and 20 ml of 5% potassium carbonate solution are added thereto. 1.54 g of 4-chlorobenzenesulphonic acid chloride in 20 ml of dioxan are added to this mixture at ambient temperature. After 5 hours it is rotary evaporated to dryness, the residue is taken up in a little sodium hydroxide solution and then precipitated with dilute acetic acid. The precipitate is collected, dried and then chromatographed over a silica gel column using chloroform/methanol (10:1) as eluant.

출처