반응 #5039

반응 방정식

water

4-cyanophenol

benzyl chloride

potassium carbonate

→

4-benzyloxybenzonitrile

용매

NMP

반응 조건

후처리

1. 1
   온도The reaction mixture was cooled to room temperature
2. 2
   기타The resulting white solid was collected
3. 3
   세척washed with water and hexanes
4. 4
   기타dried at 70° C. in vacuo

실험 절차

A mixture containing 325 g of 4-cyanophenol, 346 mL of benzyl chloride and 758 g of potassium carbonate in 1.2 L of NMP was heated at 95° C. with stirring for 1.5 hrs. The reaction mixture was cooled to room temperature and poured into 5 L of cold water. The resulting white solid was collected, washed with water and hexanes and dried at 70° C. in vacuo giving 570.0 g of 4-benzyloxybenzonitrile.

출처