반응 #50338

반응 방정식

benzaldehyde

diethyl ketone

→

5-phenyl-5-hydroxy-4-methylpentan-3-one

수율 72.0%

반응 조건

후처리

1. 1
   기타prepared by the procedure
2. 2
   여과After decantation, filtration
3. 3
   기타on hyflo-supercel and evaporation of the solvents under vacuum

실험 절차

50 mmol (5.1 ml) of benzaldehyde are added at -78° C. to the manganous enolate of diethyl ketone, prepared by the procedure described above. After stirring for 10 seconds at -78° C., the reaction medium is hydroIyzed by the dropwise addition of a saturated solution of (NH4)2SO4. After decantation, filtration on hyflo-supercel and evaporation of the solvents under vacuum, 5-phenyl-5-hydroxy-4-methylpentan-3-one is isolated by low pressure liquid chromatography on 15 μm silica gel using cyclohexane/ethyl acetate (90/10) as the eluent. Yield=72%. Erythro/threo=61/39.

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