반응 #50319

반응 방정식

N-(3-trifluoromethylphenyl)-N'-ethoxycarbonylthiourea

dibromoethane

potassium carbonate

→

2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)thiazolidine

수율 83.1%

용매

acetone

반응 조건

후처리

1. 1
   기타The solvent was removed by distillation
2. 2
   추출the residue was extracted with diethyl ether
3. 3
   세척The extract was washed with water
4. 4
   건조dried over anhydrous magnesium sulfate
5. 5
   농축concentrated under reduced pressure
6. 6
   기타The residue was recrystallized from a mixture of hexane and ethanol

실험 절차

A solution of N-(3-trifluoromethylphenyl)-N'-ethoxycarbonylthiourea (1.8 g), dibromoethane (1.29 g) and anhydrous potassium carbonate (2.6 g) in acetone (20 ml) was refluxed for 5 hours. The solvent was removed by distillation, and the residue was extracted with diethyl ether. The extract was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was recrystallized from a mixture of hexane and ethanol to give 1.63 g of 2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)thiazolidine. m.p., 75.8° C.

출처