반응 #50293

반응 방정식

water

potassium fluoride

18-crown-6

5-Chloro-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazoline

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Compound 41

5-Fluoro-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazoline

용매

DMF

반응 조건

후처리

1. 1
   온도This mixture was refluxed for 1.5 h
2. 2
   추출The aqueous solution was extracted with ethyl acetate
3. 3
   기타the organic layer was separated
4. 4
   기타dried
5. 5
   기타the solvent removed m vacuo

실험 절차

To a solution of 700 mg of potassium fluoride and 200 mg 18-crown-6 in 10 mL of DMF was added 5-Chloro-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazoline (200 mg). This mixture was refluxed for 1.5 h, cooled to room temperature and poured into water. The aqueous solution was extracted with ethyl acetate, the organic layer was separated and dried, and the solvent removed m vacuo to yield 5-Fluoro-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazoline (Compound 41), m.p. 154°-155° C.

출처