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2,6-difluoro-3-hydroxybenzenecarboxamide

5-(chloromethyl)-1-benzothiophene

1-benzothiophen-5-ylmethanol

thionyl chloride

→

3-(1-Benzothiophen-5-ylmethoxy)-2,6-difluorobenzenecarboxamide

수율 10.0%

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실험 절차

Synthesised from 2,6-difluoro-3-hydroxybenzenecarboxamide according to Method B, scheme 2. The required building block, 5-(chloromethyl)-1-benzothiophene, was synthesised by chlorination of commercially available 1-benzothiophen-5-ylmethanol with thionyl chloride. Yield 10%, mp 146-148° C., HPLC-MS (method 1): m/z 320 [M+H]+, Rt=3.95 min.

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