반응 #5023

반응 방정식

ethanol

N-acetyl-5-bromo-7-nitroindoline

hydrochloric acid

→

compound

수율 32.2%

N-acetyl-7-amino-5-bromoindoline

수율 32.2%

용매

water

반응 조건

후처리

1. 1
   온도to refluxing for 5 hours with vigorous stirring
2. 2
   여과The reaction mixture was filtered by suction while hot
3. 3
   기타to remove insoluble matter
4. 4
   농축the filtrate thereof was concentrated
5. 5
   온도cooled

실험 절차

To a mixed solution of ethanol (400 ml) and water (100 ml), were added N-acetyl-5-bromo-7-nitroindoline (133.1 g), iron powder (10 mesh; 75 g) and concentrated hydrochloric acid (5 ml), and the mixture was subjected to refluxing for 5 hours with vigorous stirring. The reaction mixture was filtered by suction while hot to remove insoluble matter, and then the filtrate thereof was concentrated and cooled on standing to give the intended compound 38.3 g (32.2%) as a brown needle crystal. M.P.: 154°-155° C.

출처