반응 #502150

ord-259821b260614d189dc30e7901e42d4f

반응 방정식

CSc1nc(Cc2cccc(Cl)c2)[nH]c(=O)c1C#N
2-(3-chlorobenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile
C1COCCN1
morpholine
N#Cc1c(N2CCOCC2)nc(Cc2cccc(Cl)c2)[nH]c1=O
title compound
N#Cc1c(N2CCOCC2)nc(Cc2cccc(Cl)c2)[nH]c1=O
2-(3-Chlorobenzyl)-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

In analogy to the preparation of Example 1, 150 mg (0.51 mmol) of 2-(3-chlorobenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile are reacted with 448 mg (5.14 mmol) of morpholine to give 109 mg (63% of theory) of the title compound.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08088769B2uspto-grants-2012_01