반응 #502147

ord-44a7c2b035cf407bb6b026d354dd1ca4

반응 방정식

CSc1nc(Cc2cccc(Cl)c2)[nH]c(=O)c1C#N
2-(3-chlorobenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile
C1CCNC1
pyrrolidine
N#Cc1c(N2CCCC2)nc(Cc2cccc(Cl)c2)[nH]c1=O
title compound
N#Cc1c(N2CCCC2)nc(Cc2cccc(Cl)c2)[nH]c1=O
2-(3-Chlorobenzyl)-6-oxo-4-(1-pyrrolidinyl)-1,6-dihydropyrimidine-5-carbonitrile

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

In analogy to the preparation of Example 1, 100 mg (0.34 mmol) of 2-(3-chlorobenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile are reacted with 244 mg (3.43 mmol) of pyrrolidine to give 29 mg (27% of theory) of the title compound.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08088769B2uspto-grants-2012_01