반응 #502141

반응 방정식

2-(3-methylbenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydro-5-pyrimidinecarbonitrile

(S)-(+)-2-pyrrolidinemethanol

→

title compound

4-[(2S)-2-(Hydroxymethyl)-1-pyrrolidinyl]-2-(3-methylbenzyl)-6-oxo-1,6-dihydro-5-pyrimidinecarbonitrile

용매

acetonitrile

반응 조건

후처리

1. 1
   기타the crude product is purified by preparative HPLC

실험 절차

0.1 g (0.37 mmol) of 2-(3-methylbenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydro-5-pyrimidinecarbonitrile is heated with 0.11 g (1.1 mmol) of (S)-(+)-2-pyrrolidinemethanol in 3 ml of acetonitrile at 90° C. under argon for five days. After cooling to room temperature, the crude product is purified by preparative HPLC. 0.035 g (29% of theory) of the title compound is obtained as a colourless solid.

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