반응 #502140

반응 방정식

2-(3-methylbenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydro-5-pyrimidinecarbonitrile

cyclopentylamine

→

title compound

4-(Cyclopentylamino)-2-(3-methylbenzyl)-6-oxo-1,6-dihydro-5-pyrimidinecarbonitrile

용매

acetonitrile

반응 조건

후처리

1. 1
   기타the crude product is purified by preparative HPLC

실험 절차

0.1 g (0.37 mmol) of 2-(3-methylbenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydro-5-pyrimidinecarbonitrile is heated with 0.31 g (3.65 mmol) of cyclopentylamine in 3 ml of acetonitrile at 90° C. under argon overnight. After cooling to room temperature, the crude product is purified by preparative HPLC. 0.03 g (26% of theory) of the title compound is obtained as a colourless solid.

출처