반응 #502138

반응 방정식

2-benzyl-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

piperidine

→

title compound

2-Benzyl-6-oxo-4-(1-piperidinyl)-1,6-dihydropyrimidine-5-carbonitrile

용매

acetonitrile

반응 조건

후처리

1. 1
   기타The resulting crude product is then purified by preparative HPLC

실험 절차

43 mg (0.17 mmol) of 2-benzyl-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile are suspended in 0.3 ml of acetonitrile and stirred with 42.7 mg (0.50 mmol) of piperidine at 85° C. for 16 h. The resulting crude product is then purified by preparative HPLC. 11 mg (22% of theory) of the title compound are obtained.

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