반응 #502137

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2-(3,4-dichlorobenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

piperidine

→

title compound

2-(3,4-Dichlorobenzyl)-6-oxo-4-(1-piperidinyl)-1,6-dihydropyrimidine-5-carbonitrile

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후처리

1. 1
   기타After removal of the volatile constituents in vacuo
2. 2
   기타the residue is purified by preparative HPLC

실험 절차

100 mg (0.34 mmol) of 2-(3,4-dichlorobenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile are stirred with 261 mg (3.07 mmol) of piperidine at 85° C. for 16 h. After removal of the volatile constituents in vacuo, the residue is purified by preparative HPLC. 42 mg (38% of theory) of the title compound are obtained.

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