반응 #502106

반응 방정식

1H-indazole-3-carboxylic acid

N,O-dimethylhydroxylamine hydrochloride

1-(3-dimethylaminopropyl)-3-ethylcarbodiimide

pyridine

→

compound

수율 69.1%

N-Methoxy-N-methyl-1H-indazole-3-carboxamide

수율 69.1%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   농축The mixture is concentrated
2. 2
   기타The yellow precipitate obtained
3. 3
   세척is washed with water
4. 4
   기타dried under reduced pressure

실험 절차

In a round-bottomed flask, 4.0 g of 1H-indazole-3-carboxylic acid, 2.6 g of N,O-dimethylhydroxylamine hydrochloride, 9.4 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide and 8.4 ml of pyridine are placed in 120 ml of tetrahydrofuran. The mixture is stirred at ambient temperature for 20 h. The mixture is concentrated and the residue is taken up in water. The yellow precipitate obtained is washed with water and then dried under reduced pressure. 3.5 g of compound are obtained.

출처