반응 #502102

반응 방정식

[4-[(2-quinolin-3-yl)imidazo[1,2-a]pyridin-6-yl]thien-2-yl]methanol

hydrochloric acid

→

compound

[4-[(2-Quinolin-3-yl)imidazo[1,2-a]pyridin-6-yl]thien-2-yl]methanol hydrochloride

용매

dichloromethane

isopropanol

methanol

반응 조건

후처리

1. 1
   workup.ADDITIONare added to the filtrate
2. 2
   농축The reaction mixture is then concentrated under reduced pressure
3. 3
   여과The precipitate is recovered by filtration
4. 4
   기타oven-dried under reduced pressure

실험 절차

100 mg of [4-[(2-quinolin-3-yl)imidazo[1,2-a]pyridin-6-yl]thien-2-yl]methanol are suspended in dichloromethane and methanol. The solution is passed through a frit and 5.6 ml of a 0.1N solution of hydrochloric acid in isopropanol are added to the filtrate. The reaction mixture is then concentrated under reduced pressure and the residue is then taken up in diethyl ether. The precipitate is recovered by filtration and oven-dried under reduced pressure. 106 mg of compound are obtained.

출처