반응 #502099

반응 방정식

2-(4-chlorophenyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-a]pyridine

hydrochloric acid

diethyl ether

→

compound

수율 199.0%

[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]boronic acid hydrochloride

수율 199.0%

용매

acetone

water

반응 조건

후처리

1. 1
   workup.STIRRINGthe mixture is stirred at ambient temperature for 24 h
2. 2
   농축The reaction mixture is then concentrated under reduced pressure
3. 3
   기타The solid obtained
4. 4
   여과recovered by filtration
5. 5
   기타dried in an oven under reduced pressure at 60° C

실험 절차

3.60 g of 2-(4-chlorophenyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-a]pyridine are dissolved in 112 ml of acetone and 56 ml of water; 101 ml of 1N hydrochloric acid are added thereto, dropwise and with stirring, and the mixture is stirred at ambient temperature for 24 h. The reaction mixture is then concentrated under reduced pressure. The solid obtained is titurated with diethyl ether and recovered by filtration, and then dried in an oven under reduced pressure at 60° C. 3.12 g of compound are obtained.

출처