반응 #502097

반응 방정식

sodium borohydride

5-[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]furan-2-carbaldehyde

→

compound

수율 37.3%

{5-[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl]furan-2-yl}methanol

수율 37.3%

용매

methanol

반응 조건

후처리

1. 1
   기타the solvent is then evaporated off under reduced pressure
2. 2
   기타The organic phase is separated
3. 3
   건조dried over sodium sulphate
4. 4
   농축concentrated under reduced pressure

실험 절차

122 mg of sodium borohydride are added, in small portions, to 104 mg of 5-[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]furan-2-carbaldehyde dissolved in 20 ml of methanol. The mixture is subsequently stirred at ambient temperature for 2 hours, and the solvent is then evaporated off under reduced pressure. The residue is taken up between dichloromethane and water. The organic phase is separated, dried over sodium sulphate and concentrated under reduced pressure. 39 mg of compound are obtained.

출처