반응 #502096

반응 방정식

2-(4-chlorophenyl)-6-iodoimidazo[1,2-a]pyridine

5-formyl-2-furanboronic acid

potassium carbonate

ethanol

→

compound

수율 38.2%

5-[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl]furan-2-carbaldehyde

수율 38.2%

용매

water

반응 조건

후처리

1. 1
   기타degassed with argon
2. 2
   기타irradiated at 90° C. for 30 min
3. 3
   온도After cooling
4. 4
   기타the catalyst is removed by filtration
5. 5
   세척washed with ethyl acetate
6. 6
   기타The organic phase is separated
7. 7
   기타dried
8. 8
   농축the filtrate is concentrated under reduced pressure
9. 9
   기타The residue is purified by silica gel chromatography, elution

실험 절차

300 mg of 2-(4-chlorophenyl)-6-iodoimidazo[1,2-a]pyridine, 118 mg of 5-formyl-2-furanboronic acid, 89 mg of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium, 280 mg of potassium carbonate, 1.5 ml of ethanol and 1 ml of water are placed in a microwave tube and degassed with argon. The tube is placed in a microwave apparatus and irradiated at 90° C. for 30 min. After cooling, the catalyst is removed by filtration and washed with ethyl acetate. The organic phase is separated and dried and the filtrate is concentrated under reduced pressure. The residue is purified by silica gel chromatography, elution being carried out with a dichloromethane/methanol mixture. 104 mg of compound are obtained.

출처