반응 #502095

반응 방정식

water

2-amino-5-iodopyridine

2-bromo-1-(4-chlorophenyl)ethanone

sodium hydrogen carbonate

→

compound

수율 68.5%

2-(4-Chlorophenyl)-6-iodoimidazo[1,2-a]pyridine

수율 68.5%

용매

n-propanol

반응 조건

후처리

1. 1
   workup.WAITleft
2. 2
   온도to cool
3. 3
   여과The precipitate is recovered by filtration
4. 4
   세척washed with water
5. 5
   기타dried under reduced pressure

실험 절차

5.0 g of 2-amino-5-iodopyridine, 5.3 g of 2-bromo-1-(4-chlorophenyl)ethanone and 2.67 g of sodium hydrogen carbonate in 150 ml of n-propanol are placed in a round-bottomed flask. The mixture is heated at 80° C. for 40 h and left to cool, and 700 ml of water are added. The precipitate is recovered by filtration, washed with water and dried under reduced pressure. 5.51 g of compound are obtained.

출처