반응 #502055

반응 방정식

3-aminophenoxyacetic acid methylester

sodium carbonate

→

3-Diallylaminophenoxyacetic acid methylester

용매

allyl bromide

반응 조건

후처리

1. 1
   여과The insoluble salt is filtered off
2. 2
   세척washed with 70 g of ethyl acetate
3. 3
   workup.WAITThe combined filtrates are kept at 5° C. for 12 h
4. 4
   추출After the extraction with water
5. 5
   건조the organic phase is dried with sodium sulfate
6. 6
   기타the solvent is removed in vacuum (60° C., 28 mbar)

실험 절차

22 g of 3-aminophenoxyacetic acid methylester are solved in 63 g allyl bromide. Subsequently, 10 g of sodium carbonate are added portionwise and the temperature is raised to 45° C. The reaction mixture is stirred at this temperature for 4.5 hours. The insoluble salt is filtered off and washed with 70 g of ethyl acetate. The combined filtrates are kept at 5° C. for 12 h. After the extraction with water, the organic phase is dried with sodium sulfate and the solvent is removed in vacuum (60° C., 28 mbar). Yield: 24 g (dark oil).

출처