반응 #50184

반응 방정식

5-bromopyridin-3-ylmethanol

tert-butylchlorodiphenylsilane

imidazole

→

product

5-Bromo-O-tert-butyldiphenylsilylpyridin-3-ylmethanol

용매

CH2Cl2

반응 조건

후처리

1. 1
   여과and filtered
2. 2
   기타The filtrate was evaporated
3. 3
   기타the residue chromatographed on silica gel eluting with a 1:7 mixture of EtOAc and hexane

실험 절차

To a solution of 5-bromopyridin-3-ylmethanol (Chem. Pharm. Bull. 1990, 38, 2446) (29 g, 154 mmoL) and tert-butylchlorodiphenylsilane (47.5 g, 173 mmoL) in CH2Cl2 (500 mL) at r.t., there was added imidazole (15.8 g, 232 mmoL). The mixture was stirred for 1 hr. and filtered. The filtrate was evaporated and the residue chromatographed on silica gel eluting with a 1:7 mixture of EtOAc and hexane, to afford the product as a colorless oil.

출처