반응 #50167

반응 방정식

(S)-2-pentanol

tetrahydrofuran

sodium hydride

bromoacetaldehyde diethylacetal

→

2-(4-methylbutyloxy)acetaldehyde diethylacetal

반응 조건

후처리

1. 1
   온도the mixture was refluxed for 6 hours
2. 2
   농축After the reaction solution were concentrated
3. 3
   workup.ADDITIONwater and ether was added
4. 4
   workup.STIRRINGthe mixture was shaken
5. 5
   workup.ADDITIONfor mixing
6. 6
   기타The organic layer was collected
7. 7
   건조was dried with magnesium sulfate
8. 8
   기타to remove the solvent off
9. 9
   기타Purification

실험 절차

35 g of (S)-2-pentanol was dissolved in tetrahydrofuran, and 16 g of 60% sodium hydride was added thereto. After stirring for 30 minutes, 80 g of bromoacetaldehyde diethylacetal was added thereto, and the mixture was refluxed for 6 hours. After the reaction solution were concentrated and water and ether was added thereto, the mixture was shaken for mixing. The organic layer was collected and was dried with magnesium sulfate to remove the solvent off. Purification was carried out by column chromatography to obtain 2-(4-methylbutyloxy)acetaldehyde diethylacetal (54).

출처