반응 #50106
ord-a254a47f4a7b42b890ab20256a72c77c
반응 방정식
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타to return to room temperature
- 2기타(1 h 30 min)
- 3추출the mixture was extracted with dichloromethane (4×10 cm3)
- 4건조The extract was dried over MgSO4
- 5여과filtered
- 6기타evaporated down
- 7기타The crude product was purified by flash chromatography on silica (eluent ether/petroleum ether=5/95)
실험 절차
2.91 cm3 (2.91 mmol) of BBr3 in molar solution in dichloromethane were introduced at 4° C. under argon atmosphere into 0.98 (5.3 mmol) of epoxide 2e in solution in 6.5 cm3 dichloromethane. The reaction mixture was then allowed to return to room temperature and stirring was continued (1 h 30 min). 5 cm3 of distilled water were then added and the mixture was extracted with dichloromethane (4×10 cm3). The extract was dried over MgSO4, filtered and evaporated down. The crude product was purified by flash chromatography on silica (eluent ether/petroleum ether=5/95): 1.03 g of alcohol 1i were obtained (macrobore GC purity>97%); the yield of product 1i was 73%.