반응 #500909

반응 방정식

2-indolinone

2-ethyl-4-formylimidazole

2-chlorotrityl resin

piperidine

→

Imidazolyl Indolinone

용매

DMF

반응 조건

후처리

1. 1
   온도heated at 80° C. for 20 h
2. 2
   여과The resin was filtered
3. 3
   세척washed with 30 ml each of acetone, water, dichloromethane, methanol
4. 4
   기타dried for 20 min.

실험 절차

A mixture of 2-ethyl-4-formylimidazole attached to 2-chlorotrityl resin (4, 78 mg, 0.052 mmol based on 0.67 mmol/g loading), DMF (0.9 ml) and piperidine (0.1 ml) was gently stirred for 45 min. at ambient temperature, afterwhich was added 2-indolinone (5, 70 mg, 0.523 mmol). The resultant mixture was gently stirred and heated at 80° C. for 20 h. The resin was filtered and washed with 30 ml each of acetone, water, dichloromethane, methanol, and another portion of acetone. Finally, the resin was air dried for 20 min.

출처