반응 #500893

반응 방정식

glutaric anhydride

N-propylpiperazine

→

5-oxo-5-(4-propylpiperazin-1-yl)pentanoic acid

수율 78.7%

용매

dioxane

dioxane

반응 조건

후처리

1. 1
   기타the solvent is evaporated under reduced pressure
2. 2
   workup.STIRRINGAfter stirring for one hour
3. 3
   기타the solid obtained
4. 4
   여과is filtered
5. 5
   기타dried at 20° C. (90 Pa)

실험 절차

1.5 g of glutaric anhydride and then 1.66 g of N-propylpiperazine in solution in 5 cm3of dioxane are added to 10 cm3 of dioxane in a round-bottomed flask kept under an argon atmosphere. After stirring for 2.5 hours at room temperature, the solvent is evaporated under reduced pressure and then the resulting oil is supplemented with 100 cm3 of diethyl ether. After stirring for one hour, the solid obtained is filtered, dried at 20° C. (90 Pa) to give 2.47 g of 5-oxo-5-(4-propylpiperazin-1-yl)pentanoic acid in the form of a white solid which is used as it is.

출처