반응 #50066

반응 방정식

Potassium phthalimide

1,5-dibromopentane

water

→

solid

5-bromopentylphthalimide

용매

dimethylformamide

반응 조건

후처리

1. 1
   온도heated to 80° C. approx.
2. 2
   추출the solution was repeatedly extracted with ether
3. 3
   세척The collected organic phases were washed with water
4. 4
   기타dried on Na2SO4
5. 5
   기타evaporated under reduced pressure

실험 절차

Potassium phthalimide (5.4 mmoles) was added to a solution of 1,5-dibromopentane (3.72 g; 16.2 mmoles) in dimethylformamide (8 ml) and heated to 80° C. approx. under stirring. After 2 hours, water was added and the solution was repeatedly extracted with ether. The collected organic phases were washed with water, dried on Na2SO4 and evaporated under reduced pressure to give a solid (4.50 g), which was purified by chromatography on silica gel (Etp/Et2O 8:2) yielding 2.38 g of a white solid. Yield 68%.

출처