반응 #5002

반응 방정식

methyl 2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-hydroxyiminomethylbenzoate

ethyl 2-bromopropionate

→

aimed compound

수율 27.0%

methyl 2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-[(1-ethoxycarbonylethyl)oxyiminomethyl)benzoate

수율 27.0%

용매

acetone

반응 조건

후처리

1. 1
   workup.WAITto stand for one night at room temperature
2. 2
   기타reaction liquor
3. 3
   workup.DISTILLATIONthe acetone was distilled off under reduced pressure
4. 4
   기타The resultant product was purified by column chromatography

실험 절차

2.0 g of methyl 2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-hydroxyiminomethylbenzoate, 3 ml of ethyl 2-bromopropionate and 0.9 g of silver oxide (I) were place in a 50 ml eggplant type flask, and were allowed to stand for one night at room temperature. 10 ml of acetone and 10 g of silica gel were added to the resultant reaction liquor, and the acetone was distilled off under reduced pressure. The resultant product was purified by column chromatography to obtain 0.7 g of the aimed compound (refractive index=1.5261) at a yield of 27%.

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