반응 #50012

반응 방정식

(-)-1-(2,3,4-Trichlorophenyl)ethanesulfonic acid

racemic 4-amino-3-mercaptobutyric acid hydrochloride

→

(3R)-4-amino--3-mercaptobutyric acid (-)-1-(2,3,4-trichlorophenyl)ethanesulfonate

수율 81.5%

용매

water

water

반응 조건

후처리

1. 1
   workup.DISSOLUTIONThe mixture is dissolved at 70° C.-80° C.
2. 2
   온도to cool
3. 3
   온도After cooling
4. 4
   온도cooling for one hour
5. 5
   여과the precipitated crystals are collected by filtration
6. 6
   세척washed
7. 7
   기타dried

실험 절차

(-)-1-(2,3,4-Trichlorophenyl)ethanesulfonic acid (3.18 g) is dissolved in water (17.4 ml), and thereto is added aqueous solution of racemic 4-amino-3-mercaptobutyric acid hydrochloride (3.77 g)in water (24.6 ml). The mixture is dissolved at 70° C.-80° C., and allowed to cool. After cooling, the mixture is stirred under ice-cooling for one hour, and the precipitated crystals are collected by filtration, washed, and dried to give (3R)-4-amino--3-mercaptobutyric acid (-)-1-(2,3,4-trichlorophenyl)ethanesulfonate (3.8 g).

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