반응 #50006
ord-4a8947eb6a0041508dc83e1f4689d2d3
반응 방정식
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1여과The solid was filtered
- 2기타the phases were separated
- 3건조the organic phase dried over magnesium sulfate
- 4농축concentrated
- 5기타The residue was purified by column chromatography (eluent: hexane/ethyl acetate)
실험 절차
A suspension of 16.9 g calcium carbonate in 100 ml water was added to a solution of 19.4 g thiophosgene in 100 ml dichloromethane. A solution of 40 g 7-amino-2,4-dichloro-6-fluorobenzothiazole in 500 ml dichloromethane was added, dropwise at 5° C., and the mixture stirred for 8 hours at room temperature. The solid was filtered, the phases were separated, and the organic phase dried over magnesium sulfate and concentrated. The residue was purified by column chromatography (eluent: hexane/ethyl acetate). Yield: 16 g=38% of theory m.p.: 80°-81° C.