반응 #4998

반응 방정식

2,3-dimethylmaleic anhydride

methyl 4-amino-2-(aminosulfonyl)benzoate

→

methyl 2-(aminosulfonyl)-4-(2,5-dihydro-3,4-dimethyl-2,5-dioxo-1H-pyrrol-1-yl)benzoate

수율 43.0%

용매

acetic acid

반응 조건

후처리

1. 1
   workup.DISTILLATIONAcetic acid was then distilled off from the reaction mixture
2. 2
   workup.ADDITIONfollowed by the addition of 20 ml of ice water to the oily residue
3. 3
   기타After the mixture thus formed
4. 4
   여과the resulting precipitate was collected by filtration
5. 5
   기타dried in air

실험 절차

In 3 ml of acetic acid, 1 mmol of methyl 4-amino-2-(aminosulfonyl)benzoate and 1.05 mmol of 2,3-dimethylmaleic anhydride were stirred at 80° C. for 40 hours. Acetic acid was then distilled off from the reaction mixture, followed by the addition of 20 ml of ice water to the oily residue. After the mixture thus formed was stirred for 2 hours, the resulting precipitate was collected by filtration and then dried in air. Yield: 43%. Its physicochemical properties are shown in Table 8.

출처