반응 #499638

반응 방정식

(R)-isoserine ethyl ester hydrochloride

N-chlorocarbamoyl-4-[(4-cyclohexylphenylamino)methyl]benzoic acid methyl ester

biphenyl-2-ylmethylamine

benzoic acid methyl ester

→

title compound

3-{4-[3-Biphenyl-2-ylmethyl-1-(4-cyclohexylphenyl)ureidomethyl]benzoylamino}-2(R)-hydroxypropionic Acid

반응 조건

후처리

1. 1
   기타This compound was prepared similarly
2. 2
   기타Hydrolysis

실험 절차

This compound was prepared similarly as described in example 35 from N-chlorocarbamoyl-4-[(4-cyclohexylphenylamino)methyl]benzoic acid methyl ester and biphenyl-2-ylmethylamine followed by hydrolysis of the benzoic acid methyl ester, coupling with (R)-isoserine ethyl ester hydrochloride. Hydrolysis afforded the title compound.

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