반응 #49960

반응 방정식

3-Phenyl-l-adamantaneacetic acid

Methyl 3-bromoadamantaneacetate

Aluminum trichloride

→

methyl 3-phenyl-1-adamantaneacetate

용매

benzene

반응 조건

후처리

1. 1
   기타The reaction mixture was then quenched by the addition of 0.5M phosphoric acid (1.6 L)
2. 2
   기타The layers were separated
3. 3
   건조the organic layer was dried over sodium sulfate
4. 4
   여과filtered
5. 5
   기타evaporated in vacuo

실험 절차

Preparation of 3-Phenyl-l-adamantaneacetic acid, a hapten. Methyl 3-bromoadamantaneacetate (80 g) (Aldrich Chemical Co. Milwaukee Wis.) was dissolved in benzene (1.6 L) under nitrogen. Aluminum trichloride (37.12 g) was added portionwise over 75 min. at ambient temperature. The reaction mixture was then quenched by the addition of 0.5M phosphoric acid (1.6 L). The layers were separated and the organic layer was dried over sodium sulfate, filtered, and evaporated in vacuo to give methyl 3-phenyl-1-adamantaneacetate (80 g).

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