반응 #49940

반응 방정식

N'-t-butyl-N-benzoyl hydrazine

2-chloromethyl pyridine

triethylamine

→

product

수율 20.0%

N'-t-butyl-N-benzoyl-N'-methylpyridinylhydrazine

수율 20.0%

용매

dimethyl sulfoxide

ether

반응 조건

후처리

1. 1
   세척washed with water
2. 2
   건조The organic layer was dried over magnesium sulfate
3. 3
   여과filtered
4. 4
   기타to afford a yellow oil
5. 5
   기타The oil was chromatographed on silica gel (G:70-230 mesh)

실험 절차

N'-t-butyl-N-benzoyl hydrazine (1.2 g), 2-chloromethyl pyridine (1.0 g) and triethylamine (2 equivalents) were stirred in dimethyl sulfoxide (15 ml) at room temperature for 2 hours. The reaction mixture was then warmed to 50° C. for 2 hours. The mixture was diluted with ether and washed with water. The organic layer was dried over magnesium sulfate, filtered and rotavapped to afford a yellow oil. The oil was chromatographed on silica gel (G:70-230 mesh) using a methylene chloride-ether mixture (1:1) as eluant to afford the purified product as a yellow gum in approximately 20% yield.

출처