반응 #4994

반응 방정식

3-ethylcarbonyl-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-oxadiazole

hydroxyamine hydrochloride

→

desired product

수율 85.0%

3-(alpha-hydroxyiminopropyl)-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-oxadiazole

수율 85.0%

용매

methanol

반응 조건

후처리

1. 1
   온도The mixture was heated
2. 2
   온도to reflux for 4 hours
3. 3
   기타After evaporation of methanol, water
4. 4
   workup.ADDITIONwas added to the residue
5. 5
   추출The aqueous solution was extracted with ethylacetate
6. 6
   기타After evaporation of ethylacetate
7. 7
   기타the residue was purified by column chromatography(benzene:ether=1.1)

실험 절차

0.9 g of 3-ethylcarbonyl-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-oxadiazole and 0.21 g of hydroxyamine hydrochloride were added to 10 ml of methanol. The mixture was heated to reflux for 4 hours. After evaporation of methanol, water was added to the residue. The aqueous solution was extracted with ethylacetate. After evaporation of ethylacetate, the residue was purified by column chromatography(benzene:ether=1.1) to provide 0.80 g of the desired product(yield: 85.0%).

출처