반응 #499313

반응 방정식

EtOAc

3-(benzyloxy)phenol

2,5-dichloronitrobenzene

cesium carbonate

→

titled product

2-[3-(Benzyloxy)phenyl]-5-chloronitrobenzene

용매

DMSO

반응 조건

후처리

1. 1
   온도cooled to room temperature
2. 2
   세척washed with water, sat. aq. NaHCO3 and brine
3. 3
   건조dried (Na2SO4)
4. 4
   여과filtered
5. 5
   농축concentrated in vacuo

실험 절차

To a solution of 3-(benzyloxy)phenol (1.145 g, 5.72 mmol) and 2,5-dichloronitrobenzene (1.154 g, 6.01 mmol) in 15 mL of DMSO was added cesium carbonate (3.72 g, 11.4 mmol). The reaction was heated to 70° C. under argon for one hour, then cooled to room temperature. The solution was poured into EtOAc, washed with water, sat. aq. NaHCO3 and brine, dried (Na2SO4), filtered, and concentrated in vacuo. The titled product was obtained as a brown oil.

출처