반응 #499240

반응 방정식

methyl chloronicotinate

potassium carbonate

4-pyridylpiperazine

18-crown-6

→

product

수율 82.0%

Methyl 2-(4-(Pyrid-4-yl)piperazin-1-yl)nicotinate

수율 82.0%

용매

DMF

반응 조건

후처리

1. 1
   여과The excess potassium carbonate was filtered off
2. 2
   농축the filtrate was concentrated
3. 3
   기타the residue was partitioned between water and ethyl acetate
4. 4
   건조After drying the organic phase over magnesium sulfate
5. 5
   농축concentrating the solvent

실험 절차

3.4 g of methyl chloronicotinate, 5.5 g of potassium carbonate, 3.3 g of 4-pyridylpiperazine and a spatula tipful of 18-crown-6 were heated at 100° C. for 5 h in 75 ml of DMF and then stirred at room temperature for 60 h. The excess potassium carbonate was filtered off, the filtrate was concentrated and the residue was partitioned between water and ethyl acetate. After drying the organic phase over magnesium sulfate and concentrating the solvent, 3.9 g (82%) of the product were obtained.

출처