반응 #499170

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thiomorpholin-3-one

4-trifluoromethyl-1-iodobenzene

→

title product

수율 23.3%

4-(4-Trifluoromethylphenyl)-thiomorpholin-3-one

수율 23.3%

반응 조건

후처리

1. 1
   기타The residue was then purified by flash chromatography

실험 절차

A mixture of thiomorpholin-3-one (500 mg, 4.27 mmol), 4-trifluoromethyl-1-iodobenzene (1.25 mL, 8.5 mmol) and copper metal (814 mg, 12.8 mmol) was heated in a sealed glass tube at 185-200° C. for 18 hours. The residue was then purified by flash chromatography to give 260 mg of the title product as a white solid.

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