반응 #498718

반응 방정식

4-cyanothiophenol

1,3-dibromopropane

K2CO3

→

sub-title compound

수율 62.1%

4-[(3-Bromopropyl)sulfanyl]benzonitrile

수율 62.1%

용매

MeCN

반응 조건

후처리

1. 1
   온도was refluxed overnight
2. 2
   여과Filtration and evaporation of the solvent
3. 3
   기타gave a brown oil that
4. 4
   기타crystallised when
5. 5
   workup.ADDITIONtreated with EtOH
6. 6
   기타The crystals were isolated by filtration

실험 절차

A mixture of 4-cyanothiophenol (20.8 g, 154 mmol), 1,3-dibromopropane (155 g, 0.77 mol) and K2CO3 (21.3 g, 154 mmol) in MeCN (300 mL) was refluxed overnight. Filtration and evaporation of the solvent gave a brown oil that crystallised when treated with EtOH. The crystals were isolated by filtration to give the sub-title compound (24.5 g, 62%).

출처