반응 #4985

반응 방정식

Iodouridine

N-propargyltrifluoroacetamide

methanol

→

alkynylamino nucleoside

5-(3-trifluoroacetamido-1-propynyl)-2', 3'-dideoxyuridine

용매

dichloromethane

반응 조건

후처리

1. 1
   기타to dry
2. 2
   기타vacuum-drying

실험 절차

Iodouridine 21 was coupled for 3 hours to N-propargyltrifluoroacetamide following the general method given in Example 5C. Chromatography with a 0-5% methanol in dichloromethane gradient afforded material which was homogeneous by TLC, but which was difficult to dry. After co-evaporating the chromatographed product several times with chloroform and vacuum-drying, 536.5 mg of alkynylamino nucleoside 22 was obtained as a white foam. This material was homogeneous by TLC and was pure by NMR except for a small amount (39 mole%; corrected yield 66%) of chloroform.

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