반응 #49840
ord-a1fada7721ab431fa350d373a4b94879
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타To a 0° C.
- 2온도the resulting mixture was cooled to 0° C
- 3기타The organic phase was separated
- 4세척washed with 5% NaHCO3 and brine
- 5건조dried (MgSO4)
- 6기타evaporated
실험 절차
To a 0° C. solution of EtMgBr in Et2O (3.0M, 570 mL, Aldrich) was slowly added m-tolunitrile (102 mL, Aldrich). After stirring at r.t. for 19 hr., benzene (300 mL) was added and the resulting mixture was cooled to 0° C. HCl (6N, 600 mL) was then slowly added. The organic phase was separated, washed with 5% NaHCO3 and brine, dried (MgSO4) and evaporated to afford the desired ketone as a yellow liquid.