반응 #49839

반응 방정식

2,6-dimethyl-γ-pyrone

→

title compound

2,6-Dimethyltetrahydropyran-4-one

용매

EtOH

반응 조건

후처리

1. 1
   여과After filtration over celite
2. 2
   기타the solvent was evaporated
3. 3
   workup.ADDITIONThe solution was then treated with celite (30 g) and PCC (48.5 g)
4. 4
   workup.ADDITIONand the reaction was diluted with Et2O (300 mL)
5. 5
   여과filtered over a pad of celite
6. 6
   기타The filtrate was evaporated to dryness
7. 7
   기타the residual solution was then chromatographed

실험 절차

A solution of 2,6-dimethyl-γ-pyrone (17 g, Aldrich) in EtOH 95% (300 mL) was hydrogenated for 3 days under 70 psi. After filtration over celite, the solvent was evaporated and replaced by CH2Cl2. The solution was then treated with celite (30 g) and PCC (48.5 g). The suspension was stirred for 3 hr. and the reaction was diluted with Et2O (300 mL) and then filtered over a pad of celite. The filtrate was evaporated to dryness and the residual solution was then chromatographed using hexane/Et2O (1:1) to give the title compound.

출처