반응 #49812

반응 방정식

2,3-Diamino-6-methylpyridine

ethyl pyruvate

→

desired compound

수율 58.0%

(3RS)-3,6-Dimethyl-3,4-dihydro-1,4,5-triazanaphthalen-2(1H)-one

수율 58.0%

용매

1,2-dimethoxyethane

반응 조건

후처리

1. 1
   여과The resulting precipitate (3.9 g) of 3,6-dimethyl-1,4,5-triazanaphthalen-2(1H)-one was filtered off with suction
2. 2
   기타dried
3. 3
   기타A reaction analogous to

실험 절차

2,3-Diamino-6-methylpyridine (3.0 g, 0.024 mol) and 3.2 ml (0.028 mol) of ethyl pyruvate were heated under reflux in 100 ml of 1,2-dimethoxyethane for 4 h. The resulting precipitate (3.9 g) of 3,6-dimethyl-1,4,5-triazanaphthalen-2(1H)-one was filtered off with suction, dried and used directly for the hydrogenation. A reaction analogous to that described for Example 1 resulted in 2.27 g (58%) of the desired compound of melting point 203°-205° C.

출처